Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1D4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often result in the NPM-ALK fusion gene, which is oncogenic.
ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing the highest sequence similarity to LTK.
It is crucial for neuronal development and function in the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.