Thermo Fisher Scientific MMP2 Monoclonal Antibody (101)
MMP2 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 101). Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. Human, Mouse, Rat 등 다종 반응성. Protein A 정제, PBS buffer, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 10 publications |
| Immunohistochemistry (IHC) | - | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 2 publications |
| Flow Cytometry (Flow) | 3–5 µg/1x10⁶ cells | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rabbit, Rhesus monkey, Rat |
| Published Species | Fish, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 101 |
| Immunogen | Recombinant protein derived from the N-terminus of human MMP-2 protein (accession # P08253, NP_004521), identical to Rhesus monkey and chimpanzee, 98% similar to rat and rabbit, 97% to mouse. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532214 |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a common activation mechanism and a conserved metal-binding active site, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play key roles in regulating angiogenesis.
MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. The MMP family includes at least 18 secreted and membrane-bound zinc endopeptidases that collectively degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins.
Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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