Thermo Fisher Scientific Acetyl-CoA Carboxylase Monoclonal Antibody (143)
인간 ACC-1 단백질의 C-말단에서 유래한 항원으로 제작된 mouse IgG1 단일클론 항체. Western blot, ICC/IF, ELISA, IP 등 다양한 응용 가능. 단백질 A로 정제된 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Acetyl-CoA Carboxylase Monoclonal Antibody (Clone 143)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 143 |
| Immunogen | Recombinant protein derived from the C-terminus of human Acetyl-CoA Carboxylase 1 (ACC-1) protein (accession # Q13085, NP_942131), identical to chimpanzee; 99% similar to rhesus monkey, 96% similar to pig and bovine, 95% similar to mouse and rat |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532219 |
Target Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.
There are two ACC forms, alpha and beta, encoded by different genes. ACC-alpha is highly enriched in lipogenic tissues.
The enzyme is regulated at multiple levels — transcriptional, translational, and post-translational — including phosphorylation/dephosphorylation of serine residues and allosteric modulation by citrate or palmitoyl-CoA.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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