Thermo Fisher Scientific CD244 Monoclonal Antibody (eBioDM244), FITC, eBioscience

Thermo Fisher Scientific CD244 Monoclonal Antibody (eBioDM244), FITC, eBioscience™

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 5 µL (0.25 µg)/test
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Product Specifications

Product Specific Information

The eBioDM244 monoclonal antibody reacts with human CD244 (2B4, p38). CD244 is a 38 kDa protein expressed on NK cells, subsets of CD8+ T cells, γδ T cells, monocytes, basophils, and eosinophils. Binding of its ligand CD48 induces NK cell activation in humans.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Pre-titrated and validated for flow cytometry using normal human peripheral blood
• Recommended Use: 5 µL (0.25 µg) per test (100 µL final volume; cell count 10⁵–10⁸ cells/test)
• Excitation/Emission: 488 nm / 520 nm (Blue Laser)
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD244 (2B4, SLAMF4) is a surface receptor expressed on NK cells and some T cells, mediating non-MHC restricted cytotoxicity. Interaction with SLAMF2 modulates NK-cell activity. Reduced SLAMF4 expression has been observed in systemic lupus erythematosus, suggesting a role in autoimmune disease pathology. CD244 dysfunction is associated with rheumatoid arthritis and lymphoproliferative syndrome. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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