Thermo Fisher Scientific Phospho-SMAD5 (Ser463, Ser465) Polyclonal Antibody
Phospho-SMAD5 (Ser463/465) 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 사용 가능. Western blot과 IHC(P) 실험에 적합하며, 인산화된 Smad5 특이적 검출. 고순도 정제 및 안정적 액상 형태로 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Smad5 around the phosphorylation site of Ser463/465 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899280 |
Product Specific Information
Antibody detects endogenous levels of Smad5 only when phosphorylated at Ser463/465.
Target Information
SMADs are members of the MAD-related family of molecules. These intracellular proteins are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta (TGF-β) superfamily.
SMADs are classified into:
- Receptor-regulated SMADs (R-SMADs): SMAD1, 2, 5, 8, and 9
- Common-mediator SMAD (Co-SMAD): SMAD4
- Inhibitory SMADs (I-SMADs): SMAD6 and 7
SMAD1, 5, 8, and 9 share high sequence homology, and antibodies recognizing common sequences are available. SMAD8 and SMAD9 are often used interchangeably in literature.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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