Thermo Fisher Scientific Phospho-SNAIL (Ser11) Polyclonal Antibody
SNAIL 단백질의 Ser11 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF 등에 사용 가능. 인간, 생쥐, 랫트 반응성. 액상 형태로 -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- PA5114645
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SNAIL around the phosphorylation site of Ser11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899281 |
Product Specific Information
Antibody detects endogenous levels of SNAIL only when phosphorylated at Ser11.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and functions in mesoderm and neural crest formation.
SNAI1 plays a critical role in tumor invasion through E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT).
In human breast cancer, expression of SNAI1 and/or its homolog SNAI2 (Slug) correlates with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis.
Snail 1 protein in stroma may serve as a potential prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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