Thermo Fisher Scientific S100A8 Monoclonal Antibody (CF-145), eBioscience
Human S100A8 단백질을 인식하는 CF-145 클론 단일클론 항체로, Western blot과 IHC에 적합합니다. 염증성 질환 및 종양 연구에 활용되며, 액상 형태로 0.5 mg/mL 농도, PBS buffer에 보관됩니다.
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Thermo Fisher Scientific S100A8 Monoclonal Antibody (CF-145), eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 5 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL | 1 publication |
| Flow Cytometry (Flow) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CF-145 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865405 |
Product Specific Information
Description:
The monoclonal antibody CF-145 recognizes human S100A8, also known as migration inhibitory factor-related protein 8 (MRP-8) or Calgranulin-A. S100A8 is a calcium-binding protein belonging to the S100 family, expressed by neutrophils, monocytes, macrophages, granulocytes, and epithelial cells during dermatoses such as psoriasis.
It forms a heterodimer with S100A9 (calprotectin) and exhibits antimicrobial, pro-apoptotic, and pro-inflammatory properties. Elevated S100A8 levels are associated with inflammatory disorders (cystic fibrosis, rheumatoid arthritis, chronic bronchitis) and various tumors (skin, breast, colon, pancreatic, ovarian cancers).
Applications Reported:
- Western blotting
- Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections
Applications Tested:
- IHC (P): ≤1 µg/mL using low pH antigen retrieval
- WB: ≤5 µg/mL using A375 cell lysate
It is recommended to titrate the antibody for optimal performance.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
The S100A8 gene encodes a member of the S100 protein family with two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus and regulate cellular processes such as cell cycle progression and differentiation.
S100 genes form a cluster on chromosome 1q21. This protein may inhibit casein kinase and act as a cytokine. Altered expression is associated with cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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