Thermo Fisher Scientific Ganglioside GM2 Chimeric Recombinant Rabbit Monoclonal Antibody (KM966)
Thermo Fisher의 Ganglioside GM2 특이적 키메라 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. ICC/IF, Flow Cytometry, ELISA 등 다양한 분석에 사용 가능하며, 고순도의 Protein A 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1:1,000 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | Assay-dependent | |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | KM966 |
| Immunogen | This chimeric antibody was generated by cloning the variable heavy and light chain sequences of murine parent antibody KM696 (IgM) and expressing it as a mouse/human IgG1. The parent antibody was raised against human GM2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Specificity: This antibody recognizes and binds ganglioside GM2.
Target Information
Ganglioside GM2 is a glycosphingolipid found in the plasma membrane of cells, particularly in the nervous system. It consists of a ceramide lipid tail and a complex carbohydrate head group containing sialic acid residues. Although its exact function is not fully understood, GM2 is believed to play roles in cell signaling, communication, and maintenance of the myelin sheath surrounding nerve cells. Mutations in genes responsible for GM2 synthesis or degradation can lead to neurological disorders such as Tay-Sachs disease and Sandhoff disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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