Thermo Fisher Scientific SRPX Polyclonal Antibody
SRPX 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫, 비인간 영장류 반응성. 액상 형태, 1 mg/mL, PBS/glycerol buffer에 보관. 종양 억제 및 자가포식 관련 연구에 적합.
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- PA5102392
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SRPX (Accession P78539), corresponding to amino acid residues N247–Q297 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851797 |
Product Specific Information
Antibody detects endogenous levels of total SRPX.
Target Information
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye under glaucoma conditions. Its expression is significantly downregulated in various cancer cell lines and malignant tumor tissues. Ectopic expression induces apoptosis through the endoplasmic reticulum and activation of caspase-12, -9, and -3, suggesting a tumor suppressor role.
SRPX1 also regulates autophagy under low serum conditions and associates with Rab24, a member of the Rab GTPase family involved in autophagy. This association is enhanced during autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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