Thermo Fisher Scientific RASSF1 Polyclonal Antibody
RASSF1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트에 반응하며, 고순도의 Affinity chromatography 정제 방식으로 제조되었습니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RASSF1 (Accession Q9NS23), corresponding to amino acid residues G162–K212. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851790 |
Product Specific Information
Antibody detects endogenous levels of total RASSF1.
Target Information
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of various cancers, suggesting a tumor suppressor function. Inactivation of this gene correlates with hypermethylation of its CpG-island promoter region. The encoded protein interacts with DNA repair protein XPA and inhibits the accumulation of cyclin D1, inducing cell cycle arrest. Seven alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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