Thermo Fisher Scientific DEFB121 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DEFB121 protein. Validated for WB, IHC(P), and ICC/IF applications. Detects endogenous DEFB121 levels. Suitable for research use in immune defense and reproductive biology studies.
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- PA5102387
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Thermo Fisher Scientific DEFB121 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DEFB121 (Accession Q5J5C9), corresponding to amino acid residues V39–V76 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815920 |
Product Specific Information
Antibody detects endogenous levels of total DEFB121.
Target Information
Beta-defensins (BDs or hBDs in humans) are small cationic peptides with broad-spectrum antimicrobial activity against viruses, fungi, and bacteria. They are produced in mucosal epithelia and neutrophils and are developmentally regulated. Beta-defensin proteins share a conserved defensin motif with multiple cysteine residues and a stable tertiary structure.
Beyond their role in host immune defense, many beta-defensins contribute to sperm maturation and capacitation. Beta-defensin 121 is a 76-amino acid secreted protein likely containing a signal peptide requiring proteolytic cleavage for activation. It is highly expressed in the epididymal caput and corpus, with low expression in testis, and is not regulated by androgens.
Usage Note
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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