Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피로 정제. 액상 형태, 4°C 또는 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MYH9. Recombinant protein control fragment (Product #RP-108228) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791820 |
Product Specific Information
Immunogen sequence:
LEDATETADA MNREVSSLKN KLRRGDLPFV VPRRMARKGA GDGSDEEVDG KADGAEAKPA
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes. Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids. This protein is part of a hexameric complex composed of two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and is involved in cellular activities such as:
- Cell migration
- Adhesion
- Division
- Maintenance of cell shape
Mutations in MYH9 can result in autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including:
- May-Hegglin anomaly
- Fechtner syndrome
- Epstein syndrome
These disorders are primarily characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts. MYH9 also plays a crucial role in hematopoiesis, essential for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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