Thermo Fisher Scientific Ankyrin B Monoclonal Antibody (2.2)
Ankyrin B 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 단백질 A로 정제된 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | View 2 publications |
| ELISA | Assay-dependent | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Fruit fly, Hamster, Insect, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2.2 |
| Immunogen | Synthetic peptide derived from the human ankyrin B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533115 |
Target Information
This gene encodes a member of the ankyrin family of proteins that link integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in cell motility, activation, proliferation, contact, and maintenance of specialized membrane domains. Most ankyrins consist of three structural domains:
- An amino-terminal domain with multiple ankyrin repeats
- A central region with a highly conserved spectrin-binding domain
- A carboxy-terminal regulatory domain that is less conserved and variable
The protein encoded by this gene is essential for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene are associated with long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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