Thermo Fisher Scientific NFkB p50 Monoclonal Antibody (5D10)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15860 targets NFKB1 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human NFKB1 expressed in E. coli.
MA5-15860 detects NFKB1, which has a predicted molecular weight of approximately 50 kDa / 105 kDa.

Target Information

NF-κB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products. It regulates cellular events including cell growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-κB, is a member of the Rel protein family. It is synthesized as a p105 precursor protein and contains an N-terminal conserved RHD region with nuclear localization, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65 to form the functional NF-κB complex. It directs nuclear translocation and DNA binding of NF-κB. NF-κB has been implicated in conditions such as AIDS, hematogenic cancer cell metastasis, and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.