Thermo Fisher Scientific GNAS Polyclonal Antibody
Thermo Fisher Scientific의 GNAS Polyclonal Antibody는 인간 및 생쥐 시료에서 GNAS 단백질 검출에 적합한 토끼 IgG 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 고순도의 Protein A 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human GNAS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609911 |
Product Specific Information
- Peptide sequence: SGKSTIVKQM RILHVNGFNG DSEKATKVQD IKNNLKEAIE TIVAAMSNLV
- Sequence homology:
- Cow: 93%
- Human: 100%
- Mouse: 100%
- Pig: 100%
- Rabbit: 93%
- Rat: 100%
Target Information
Mutations in the GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins derived from alternatively spliced transcripts with alternate 5′ exons. Each upstream exon lies within a differentially methylated region, commonly found in imprinted genes. The close proximity (14 kb) of two oppositely expressed promoter regions is unusual.
One of the alternate 5′ exons introduces a frameshift relative to the other transcripts, resulting in one isoform structurally unrelated to the others. An antisense transcript exists and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which exhibits an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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