Thermo Fisher Scientific GNAS Polyclonal Antibody
Thermo Fisher Scientific의 GNAS Polyclonal Antibody는 인간 GNAS 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 고순도 친화 크로마토그래피 정제 및 액상 형태로 제공됩니다.
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Applications
- Western Blot (WB): 1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human GNAS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609910 |
Product Specific Information
Peptide sequence:
VYRATHRLLL LGAGESGKST IVKQMRILHV NGFNGEGGEE DPQAARSNSDSequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 93%
Rat: 100%
Target Information
Mutations in the GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and certain pituitary tumors.
This gene exhibits a complex imprinted expression pattern, producing maternally, paternally, and biallelically expressed proteins from alternatively spliced transcripts with alternate 5’ exons. Each upstream exon resides in a differentially methylated region typical of imprinted genes. The proximity (14 kb) of oppositely expressed promoter regions is unusual. One alternate 5’ exon introduces a frameshift, yielding a structurally distinct isoform. An antisense transcript may regulate imprinting in this region.
Mutations in GNAS are linked to pseudohypoparathyroidism type 1a (PHP1a), with an atypical autosomal dominant inheritance requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명:
PA5-42229_GNAS_O95467-1_Rabbit.svg
PA5-42229_GNAS_O95467-1_Rabbit_PDP.jpeg
PA5-42229_GNAS_P63092-1_Rabbit.svg
PA5-42229_GNAS_P63092-1_Rabbit_PDP.jpeg
PA5-42229_GNAS_Q5JWF2-1_Rabbit.svg
PA5-42229_GNAS_Q5JWF2-1_Rabbit_PDP.jpeg
PA5-42229_GNAS_P84996-1_Rabbit.svg
PA5-42229_GNAS_P84996-1_Rabbit_PDP.jpeg)
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