Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI6B2), TrueMAB
인간 NEDD4 단백질(aa 160-460)에 특이적인 마우스 단클론 항체로, Western blot에 최적화됨. TrueMAB 포맷으로 높은 특이성과 재현성 제공. 무보존제, 동결건조 형태로 안정적 보관 가능. 연구용으로만 사용.
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Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI6B2), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT domain and four WW domains.
It participates in degradation of VEGFR-2/KDFR independently of its ubiquitin-ligase activity and acts as a potential proto-oncogene by negatively regulating PTEN through ubiquitination.
NEDD4 is involved in viral budding and regulation of epithelial Na⁺ channels, influencing arterial hypertension.
Localized to the sarcolemmal region of muscle fibers, increased NEDD4 expression is associated with unloaded or denervated muscles and decreased Notch1 expression, acting as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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