Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI5A8), TrueMAB
인간 NEDD4 단백질에 특이적인 단클론 항체로 Western blot에 적합. 정제된 IgG1 마우스 항체로, 동결건조 형태로 제공. PBS 완충액에 트레할로스 포함, -20°C에서 보관. 연구용으로만 사용 가능.
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- CF812642
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- pk
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It participates in the degradation pathway of VEGFR-2/KDFR, independent of ubiquitin-ligase activity, and functions as a potential proto-oncogene by negatively regulating PTEN via ubiquitination.
NEDD4 is also involved in viral budding and regulation of epithelial Na⁺ channels, influencing arterial hypertension.
It localizes to the sarcolemmal region of muscle fibers, and its increased expression is associated with muscle unloading, denervation, and decreased Notch1 expression, acting as a downregulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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