Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI7A1), TrueMAB
인간 NEDD4 단백질(aa 160-460)을 항원으로 제작된 마우스 단클론 항체. Western blot에 최적화되어 있으며, PBS 기반 완충액에 동결건조 형태로 제공. 연구용으로만 사용 가능하며, 재구성 후 1 mg/mL 농도로 사용 권장.
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- CF812647
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- pk
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It is involved in VEGFR-2/KDFR degradation pathways, acts as a potential proto-oncogene regulating PTEN via ubiquitination, and participates in viral budding processes.
NEDD4 also regulates epithelial Na⁺ channels, influencing arterial hypertension. It localizes to the sarcolemmal region of muscle fibers, where increased expression is associated with muscle unloading and reduced Notch1 expression, acting as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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