Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
인간 Caspase 12 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, ER 스트레스 관련 세포사멸 연구에 활용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보존.
- 카탈로그번호
- PA585716
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- pk
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Caspase 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.13 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792855 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: 293T, A431, HeLa, HepG2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main routes, involving key apoptotic proteases caspase-8 and caspase-9, respectively. The endoplasmic reticulum (ER) stress pathway is the third apoptotic route, in which caspase-12 is involved.
Caspase-12 is localized to the ER but not to the cytoplasm or mitochondrion. It is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 co-localizes in the ER with proteins involved in Alzheimer’s disease, such as gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta and is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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