Thermo Fisher Scientific ATM Polyclonal Antibody
ATM 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. DNA 손상 복구 연구 및 세포주 기반 실험에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ATM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.14 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792851 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: HeLa, H1299.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein of the phosphoinositide 3-kinase (PI3K) superfamily that phosphorylates proteins involved in cell-cycle regulation, such as P53, Mdm2, BRCA1, and SMC1.
ATM plays a critical role in repairing double-stranded DNA breaks induced by ionizing radiation and other mutagens.
Its C-terminal region is homologous to catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation, leading to activation of downstream kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM has also been linked to apoptosis through interactions with Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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