Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: HeLa, H1299.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein of the phosphoinositide 3-kinase (PI3K) superfamily that phosphorylates proteins involved in cell-cycle regulation, such as P53, Mdm2, BRCA1, and SMC1.
ATM plays a critical role in repairing double-stranded DNA breaks induced by ionizing radiation and other mutagens.
Its C-terminal region is homologous to catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation, leading to activation of downstream kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM has also been linked to apoptosis through interactions with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.