Thermo Fisher Scientific HEY1 Monoclonal Antibody (4A3)
HEY1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 ELISA에 적합. Notch 신호전달 관련 연구에 유용하며, 고순도 Affinity chromatography로 정제됨. PBS buffer에 보존되며 -20°C에서 안정적 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A3 |
| Immunogen | HEY1 (NP_036390, 181 a.a. approximately 288 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GTVFGHHPHI AHPLLLPQNG HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSFGPV LPVVTSASKL SLPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAA
Target Information
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) belongs to the HEY family and is a Notch Signaling Pathway Protein.
It contains one basic helix-loop-helix (bHLH) domain and one Orange domain.
HEY1 acts as a downstream effector of Notch signaling, required for cardiovascular development.
It functions as a transcriptional repressor binding preferentially to the canonical E-box sequence 5'-CACGTG-3'.
HEY1 represses transcription by cardiac transcriptional activators GATA4 and GATA6 and is expressed during nervous system development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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