Thermo Fisher Scientific HEY1 Monoclonal Antibody (3E5)
HEY1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3E5). Western blot과 ELISA에 적합하며, 높은 특이성과 재현성을 제공. 연구용으로 Notch 신호전달 및 심혈관 발달 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E5 |
| Immunogen | HEY1 (NP_036390, 181 a.a. approximately 288 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GTVFGHHPHI AHPLLLPQNG HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSFGPV LPVVTSASKL SLPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAA
Target Information
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) belongs to the HEY family and is a Notch Signaling Pathway protein.
It contains one basic helix-loop-helix (bHLH) domain and one Orange domain.
HEY1 acts as a downstream effector of Notch signaling, required for cardiovascular development.
It functions as a transcriptional repressor binding preferentially to the canonical E-box sequence (5’-CACGTG-3’) and represses transcription by cardiac activators GATA4 and GATA6.
HEY1 is also expressed during nervous system development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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