Thermo Fisher Scientific PRL3 Polyclonal Antibody
PRL3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 50% glycerol buffer에 보관. 인간 시료 반응성이 높으며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Tyrosine Phosphatase Type IVA 3 (amino acids 1–170 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903875 |
Target Information
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are signaling molecules that regulate various cellular processes. This class contains a PTP domain and a C-terminal prenylation motif. Studies in mice indicate these proteins are prenylated in vivo and associated with the plasma membrane. Overexpression in mammalian cells inhibits angiotensin-II induced calcium mobilization and promotes cell growth. Two alternatively spliced variants exist. PRL-3 expression is upregulated in human liver carcinoma and is associated with colorectal cancer metastasis to the liver. It is also expressed in tumor metastasis and vasculature, regardless of tumor type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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