Thermo Fisher Scientific MMP13 Monoclonal Antibody (OTI3F5), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MMP13 (collagenase 3) is involved in the degradation of extracellular matrix proteins such as fibrillar collagen, fibronectin, TNC, and ACAN.
It cleaves triple-helical collagens (types I, II, and III) with highest activity for soluble type II collagen, and can also degrade collagen types IV, XIV, and X.
MMP13 plays a critical role in wound healing, tissue remodeling, cartilage degradation, bone development, mineralization, and ossification.
Mutations in the MMP13 gene are associated with skeletal disorders such as spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.