Thermo Fisher Scientific MMP13 Monoclonal Antibody (OTI3F5), TrueMAB
Human MMP13 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western Blot 및 IHC(Paraffin) 분석에 적합합니다. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. Affinity chromatography로 정제된 고순도 연구용 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 104–471 of human MMP13 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MMP13 (collagenase 3) is involved in the degradation of extracellular matrix proteins such as fibrillar collagen, fibronectin, TNC, and ACAN.
It cleaves triple-helical collagens (types I, II, and III) with highest activity for soluble type II collagen, and can also degrade collagen types IV, XIV, and X.
MMP13 plays a critical role in wound healing, tissue remodeling, cartilage degradation, bone development, mineralization, and ossification.
Mutations in the MMP13 gene are associated with skeletal disorders such as spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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