Thermo Fisher Scientific PIK3CG Monoclonal Antibody (OTI4D3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member. It generates the important second messenger PIP2 and primarily signals downstream of GPCRs, unlike class IA enzymes that act downstream of receptor tyrosine kinases.
This enzyme phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring and modulates extracellular signals, including those mediated by E-cadherin-dependent cell adhesion. It plays a key role in maintaining epithelial integrity and regulating NK cell cytotoxicity.
The gene is located in a commonly deleted region of chromosome 7, associated with myeloid leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.