Thermo Fisher Scientific PIK3CG Monoclonal Antibody (OTI2B1), TrueMAB
PIK3CG 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot 및 IHC(Paraffin) 분석에 적합합니다. HEK293T 세포에서 생산된 full-length human recombinant protein을 면역원으로 사용했으며, carrier-free 형태로 제공되어 결합 실험에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B1 |
| Immunogen | Full length human recombinant protein of human PIK3CG produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, generating the second messenger PIP2. Unlike class IA enzymes that signal via receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs.
This enzyme phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring and modulates extracellular signals, including those from E-cadherin-mediated cell-cell adhesion, crucial for epithelial integrity.
Additionally, PIK3CG plays a role in NK cell cytotoxicity regulation and is located in a chromosome 7 segment frequently deleted in myeloid leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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