Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI6C6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended desalting product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and necessary for the expression of glucose transporter.
It phosphorylates and activates MAPK14/p38-MAPK, and can be activated by insulin.
Expression of the RAS oncogene leads to accumulation of active MAP2K3, causing constitutive MAPK14 activation and oncogenic transformation of primary cells.
Inhibition of this kinase is linked to the pathogenesis of Yersinia pseudotuberculosis.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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