Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI6B12), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and is necessary for glucose transporter expression. It phosphorylates and activates MAPK14/p38-MAPK and can be activated by insulin.
RAS oncogene expression results in accumulation of the active kinase form, leading to constitutive activation of MAPK14 and oncogenic transformation of primary cells.
Inhibition of this kinase is implicated in the pathogenesis of Yersinia pseudotuberculosis.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.