Thermo Fisher Scientific LPIN3 Polyclonal Antibody
Human LPIN3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200–1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 40% 글리세롤 포함. 연구용으로 4°C 또는 -20°C에서 보관.
- 카탈로그번호
- PA562663
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LPIN3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LPIN3. Recombinant protein control fragment (Product # RP-99435) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2643443 |
Product Specific Information
Immunogen sequence:
FFVQELESDD EHVPPGLCTS PIPWGGLSGF PSDSQLGTAS EPEGLVMAGT ASTGRRKRRR RRKPKQKEDA VATDSSP
Highest antigen sequence identity to the following orthologs:
- Mouse: 73%
- Rat: 75%
Target Information
Human lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin.
Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy.
Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes and three human homologs.
Human LPIN1 gene has been mapped to 2p25; linkages of fat mass and serum leptin levels to this same region have been noted.
Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11–q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.