Thermo Fisher Scientific CD223 Polyclonal Antibody
인간 LAG-3(CD223) 단백질을 인식하는 Goat Polyclonal 항체로, Western blot에 적합합니다. Ammonium sulfate로 정제된 액상 항체이며 0.5 mg/mL 농도입니다. TBS(pH 7.3) 버퍼에 0.5% BSA와 0.02% sodium azide가 포함되어 있습니다.
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Applications
Tested Application
- Western Blot (WB): 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence EDVSQAQAGTYTCH (aa 321–334) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933949 |
Product Specific Information
- This antibody is expected to recognize the extracellular domain.
- Tested in Peptide ELISA: antibody detection limit dilution 1:2,000.
Target Information
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4.
It binds to MHC class II with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
Surface expression of LAG-3 is reported on activated T cells (including regulatory T cells) and NK cells.
CD8+ T cells usually express LAG-3 at higher levels than CD4+ T cells.
Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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