Thermo Fisher Scientific SUPV3L1 Polyclonal Antibody
SUPV3L1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능하며 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체로 미토콘드리아 RNA 대사 연구에 적합.
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- PA576460
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human SUPV3L1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720187 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
SUPV3L1 is a major helicase involved in mitochondrial RNA metabolism and functions as a component of the mitochondrial degradosome (mtEXO) complex. It degrades 3′ overhang double-stranded RNA in a 3′-to-5′ direction in an ATP-dependent manner. The protein participates in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. It acts as an ATPase and multisubstrate helicase capable of unwinding dsDNA, dsRNA, and RNA/DNA heteroduplexes in the 5′-to-3′ direction. SUPV3L1 plays a critical role in mitochondrial RNA surveillance, regulating mRNA stability, removing aberrantly formed transcripts, and degrading noncoding intermediates. It is also implicated in recombination and chromatin maintenance pathways and may protect cells from apoptosis by associating with mitochondrial DNA. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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