Thermo Fisher Scientific Protein APC Monoclonal Antibody (KT45)

Thermo Fisher Scientific Protein APC Monoclonal Antibody (KT45)

Applications and Tested Dilutions

• Western Blot (WB): 1:250
• Immunocytochemistry (ICC/IF): 1:50

Product Specifications

Product Specific Information

This antibody detects primarily full-length APC at approximately 300 kDa in human Hct116 cells, mouse brain, and rat PC12 cells.
In immunocytochemistry, APC is detected in clusters at the plasma membrane and at the ends of microtubules.

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is involved in cell migration, adhesion, transcriptional activation, and apoptosis.
Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that often progresses to malignancy.
Disease-associated mutations are typically clustered in the mutation cluster region (MCR), resulting in truncated protein products.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.