Thermo Fisher Scientific Protein APC Monoclonal Antibody (KT44)

Thermo Fisher Scientific Protein APC Monoclonal Antibody (KT44)

Applications and Tested Dilution

• Western Blot (WB): 1:1,000
• Immunocytochemistry (ICC/IF): 1:100

Product Specifications

Product Specific Information

This antibody detects full-length APC at 300 kDa and proteolytic fragments of APC at lower molecular weights.
It detects APC or its fragments in SW480, CaCO2, DLD-1, and Hct116 cells.
In immunocytochemistry, the antibody detects APC in clusters at the plasma membrane and at the ends of microtubules.

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in processes including cell migration and adhesion, transcriptional activation, and apoptosis.
Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy.
Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.