Thermo Fisher Scientific Caveolin 1 Monoclonal Antibody (7C8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:2,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20

-

Immunocytochemistry (ICC/IF)

1:125

View 3 publications 3 publications

Flow Cytometry (Flow)

Assay-dependent

-

Immunoprecipitation (IP)

1-3 µL

-

Product Specifications

Species Reactivity

Hamster, Human, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7C8

Immunogen

Intercellular membrane protein-containing vesicles (containing GLUT4) from rat. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Caveolin 1,uniProtId:P41350-1,ncbiNodeId:10114,antigenRange:1-178,antigenLength:178,antigenImageFileName:MA3-600_Caveolin_1_P41350-1_House_mouse.svg,antigenImageFileNamePDP:MA3-600_Caveolin_1_P41350-1_House_mouse_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_779568

Product Specific Information

MA3-600 detects caveolin from human, rat and hamster samples.

MA3-600 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a 19-21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65-70 kDa.

The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.

Target Information

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.