Thermo Fisher Scientific Caveolin 1 Monoclonal Antibody (7C8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA3-600 detects caveolin from human, rat and hamster samples.
It has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures.
By Western blot, this antibody detects a 19–21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65–70 kDa.
The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes.
It interacts directly with G-protein alpha subunits and regulates their activity.
Caveolin-1 is involved in the co-stimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
It can bind with DPP4 and induce T-cell proliferation and NF-κB activation in a T-cell receptor/CD3-dependent manner.
Mutations in the CAV1 gene can lead to congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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