Thermo Fisher Scientific CRMP5 Monoclonal Antibody (CR-3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50-1:1,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50

-

Immunohistochemistry (Frozen) (IHC (F))

1:50 - 1:400

-

Immunocytochemistry (ICC/IF)

1:250

-

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Published species

Human

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

CR-3

Immunogen

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View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2094649

Product Specific Information

MA3-700 detects human, bovine, rat and mouse N-terminal region of CRMP5.

MA3-700 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects an ~ 62 kDa protein corresponding to human CRMP5 from brain extract.

The MA3-700 antigen is a purified protein from human brain. This antibody is specific for the N-terminal region, amino acids 1-64. Not reactive with other CRMP isoforms.

Target Information

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.