Thermo Fisher Scientific CRMP5 Monoclonal Antibody (CR-1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20

-

Immunohistochemistry (Frozen) (IHC (F))

1:200

-

Immunocytochemistry (ICC/IF)

1:250

-

Product Specifications

Species Reactivity

Bovine, Human, Rat

Published species

Human

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

CR-1

Immunogen

CRMP5 protein purified from human brain. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CRMP5,uniProtId:Q9BPU6-1,ncbiNodeId:9606,antigenRange:1-564,antigenLength:564,antigenImageFileName:MA3-701_CRMP5_Q9BPU6-1_Rat.svg,antigenImageFileNamePDP:MA3-701_CRMP5_Q9BPU6-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2094646

Product Specific Information

MA3-701 detects human, bovine, rat and C-terminal region of CRMP5. This antibody has not been shown to be reactive in mouse samples.

MA3-701 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects an ~ 62 kDa protein corresponding to human CRMP5 from brain extract.

The MA3-701 antigen is a purified protein from human brain. This antibody is specific for the C-terminal region, amino acids 369 - 564. Not reactive with other CRMP isoforms.

Target Information

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.