Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

Antiserum specifically reacts with an 85 kDa cyclin T1 protein from human, rat, and mouse tissue.
No reaction was observed against other related cyclins.
Cross-reactivity with cyclin T1 from other species may also occur.

Target Information

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 and is a major subunit of positive transcription elongation factor b (p-TEFb).
In humans, multiple forms of p-TEFb exist, composed of various cyclins and CDK9.
The complex acts as a cofactor for HIV-1 Tat protein, essential for full activation of viral transcription.
Cyclin T1 and its kinase partner trigger transcript elongation via phosphorylation of the carboxy-terminal domain of RNA polymerase II.
Overexpression of this gene is implicated in tumor growth.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.