Thermo Fisher Scientific CDK9 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

Antiserum specifically reacts with a 43 kDa CDK9 (PITALRE) protein from human, rat, and mouse tissue. No reaction was observed against other related cyclin-dependent kinases. Cross-reactivity with CDK9 (PITALRE) from other species may also occur.
The murine cDNA is shown to be 98% identical with human. Suitable for immunohistochemistry with paraffin-embedded tissue.

Target Information

CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with Cyclin T1, playing a key role in regulating the eukaryotic cell cycle.
It regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors and promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis.
The CDK9/cyclin-K complex also phosphorylates the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro.
Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.