Thermo Fisher Scientific DAAM1 Monoclonal Antibody (5D3)
DAAM1 단백질을 인식하는 Mouse monoclonal antibody (Clone 5D3). Western blot과 Immunocytochemistry에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5D3 |
| Immunogen | Clone 5D3 was generated from a recombinant protein that included amino acid residues from the N-terminal region of human DAAM1. This sequence has less than 50% homology to the N-terminal region of DAAM2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942693 |
Product Specific Information
This antibody detects a 125 kDa protein corresponding to the apparent molecular mass of DAAM1 on SDS-PAGE immunoblots of human A431, K562, and mouse C2C12 cells.
Target Information
DAAM1 is a diaphanous-related formin first studied as a novel Disheveled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. Like other formins, DAAM1 directs nucleation and elongation of new actin filaments via its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. DAAM1 binds the Wnt receptor-associated protein Disheveled and the GTP-bound form of RhoA, promoting its active state in cells. The protein contains a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), a coiled-coil region, FH1, FH2, and a C-terminal diaphanous auto-regulatory domain (DAD). In humans, the DAAM1 gene is located on chromosome 14q23.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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