Thermo Fisher Scientific Phospho-MAP2K4 (Thr261) Polyclonal Antibody
MAP2K4의 Thr261 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P)에서 사용 가능. Human, Mouse, Rat에 반응하며, 순차 크로마토그래피로 정제됨. PBS 기반 버퍼, 50% 글리세롤 포함, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K4 (Accession P45985), corresponding to amino acid residues around phosphorylated Thr261. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816382 |
Product Specific Information
This antibody detects endogenous levels of MEK4/MKK4 only when phosphorylated at Threonine 261.
Target Information
MAP2K4 (MEK4) is a serine/threonine kinase of the STE7 family that phosphorylates and activates JNK1/2 as well as p38. It preferentially phosphorylates the tyrosine residue of JNKs and mediates various physiological and pathological processes, including responses to cellular stress and inflammatory cytokines. MAP2K4 plays roles in carcinogenesis; loss-of-function mutations have been observed in lung and pancreatic tumors, while pro-oncogenic activity has also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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