Thermo Fisher Scientific Phospho-MAP2K4 (Ser80) Polyclonal Antibody
Phospho-MAP2K4 (Ser80) 특이적 폴리클로날 항체로, 인산화된 MEK4/MKK4 단백질 검출에 적합합니다. Western blot 및 IHC(P)에서 검증되었습니다. 사람, 생쥐, 랫트 반응성. 고순도 정제 및 안정한 PBS/glycerol 보존. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K4 (Accession P45985), corresponding to amino acid residues around phosphorylated Ser80. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816381 |
Product Specific Information
This antibody detects endogenous levels of MEK4/MKK4 only when phosphorylated at Serine 80.
Target Information
MAP2K4 (MEK4) is a serine/threonine kinase of the STE7 family that phosphorylates and activates JNK1/2 and p38. It preferentially phosphorylates the tyrosine residue of JNKs and mediates responses to cellular stress and inflammatory cytokines. MAP2K4 plays roles in carcinogenesis; loss-of-function mutations have been observed in lung and pancreatic tumors, while pro-oncogenic activity has also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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