Thermo Fisher Scientific Phospho-PLA2G4A (Ser505) Polyclonal Antibody
Phospho-PLA2G4A (Ser505) 특이적 폴리클로날 항체로, 인산화된 c-PLA2 검출에 적합합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 고순도 정제 및 안정적 PBS/glycerol 저장 버퍼를 제공합니다. 연구용 전용 제품입니다.
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Thermo Fisher Scientific Phospho-PLA2G4A (Ser505) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PLA2G4A (Accession P47712), corresponding to amino acid residues around phosphorylated Ser505 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816386 |
Product Specific Information
This antibody detects endogenous levels of c-PLA2 only when phosphorylated at Serine 505.
Target Information
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid, which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca²⁺ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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