Thermo Fisher Scientific GDAP1 Polyclonal Antibody
Thermo Fisher Scientific의 GDAP1 Polyclonal Antibody는 인간 GDAP1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GDAP1. Recombinant protein control fragment (Product #RP-90927). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641932 |
Product Specific Information
- Immunogen sequence:
PLSEHNEPWF MRLNSTGEVP VLIHGENIIC EATQIIDYLE QTFLDERTPR LMPDKESMYY - Highest antigen sequence identity to orthologs:
Mouse – 93%, Rat – 97%
Target Information
Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although GDAP1 (ganglioside-induced differentiation-associated protein 1) shares the carboxy and amino-terminal GST domains, it is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, both unusual for GST family members. GDAP1 may function in a signal transduction pathway responsible for ganglioside-induced neurite differentiation and may protect myelin membranes from free-radical damage.
Mutations in the GDAP1 gene cause various forms of Charcot-Marie-Tooth disease, a common inherited peripheral nervous system disorder characterized by reduced nerve conduction velocity, progressive distal muscle atrophy, and absent deep tendon reflexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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