Thermo Fisher Scientific PTGIS Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PTGIS. Recombinant protein control fragment (Product #RP-90174). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PTGIS,uniProtId:Q16647-1,ncbiNodeId:9606,antigenRange:178-322,antigenLength:500,antigenImageFileName:PA5-53132_PTGIS_Q16647-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53132_PTGIS_Q16647-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646110

Product Specific Information

Immunogen sequence: LTLYGIEALP RTHESQAQDR VHSADVFHTF RQLDRLLPKL ARGSLSVGDK DHMCSVKSRL WKLLSPARLA RRAHRSKWLE SYLLHLEEMG VSEEMQARAL VLQLWATQGN MGPAAFWLLL FLLKNPEALA AVRGELESIL WQAEQ

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 85%.

Target Information

CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.