Thermo Fisher Scientific Phospho-GluR1 (Ser849) Polyclonal Antibody
Phospho-GluR1 (Ser849) 특이적 폴리클로날 항체로 Western blot 및 IHC(Paraffin) 실험에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도(>95%) 제품. 신경세포 내 GluR1 인산화 연구용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human GluR1 around the phosphorylation site of Serine 849 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553776 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 102 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces a conformational change that opens the cation channel, converting the chemical signal to an electrical impulse. The receptor then rapidly desensitizes and enters a transient inactive state. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization characterized by delayed current flux accumulation upon continued glutamate application.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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