Thermo Fisher Scientific Phospho-GAB1 (Tyr627) Polyclonal Antibody
GAB1 단백질의 Tyr627 인산화 부위를 특이적으로 인식하는 폴리클로날 항체입니다. 인간 및 생쥐 시료에 반응하며 Western blot에 사용 가능합니다. 고순도(>95%)로 정제되어 있으며, 세포 성장 및 신호전달 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: Refer to Thermo Fisher Scientific reference list
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Gab1 around the phosphorylation site of Tyrosine 627 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553775 |
Product Specific Information
- Detects endogenous protein at molecular weights of 76 and 110 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Gab1 is a 115 kDa multiple docking protein essential for cellular growth, transformation, and apoptosis. It can be phosphorylated by various receptor tyrosine kinases (RTKs), including:
- Insulin receptor (IR)
- Platelet-derived growth factor receptor beta (PDGFRβ)
- Hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met)
- Epidermal growth factor receptor (EGF)
Gab1 is tyrosine phosphorylated on at least 16 sites, serving as binding sites for PI3K, Grb2, PLCγ1, Nck, and SHP2.
Phosphorylation at Tyr627 and Tyr659 is critical for SHP2 binding and activation of the ERK/MAPK pathway in response to EGF.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-36846_GAB1_Q13480-1_Rabbit.svg, PA5-36846_GAB1_Q13480-1_Rabbit_PDP.jpeg)
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