Thermo Fisher Scientific L3MBTL1 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-C213)
L3MBTL1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 모노클로날 항체. ICC, Flow Cytometry, ELISA, IP, ChIP 등 다양한 응용 가능. HEK293 발현, Protein A 정제, 1 mg/mL 농도, 비결합형 액상 항체. 인간 반응성, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C213 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing L3MBTL1 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074776 |
Product Specific Information
Specificity: This antibody recognizes L3MBTL1 (Lethal(3)malignant brain tumor-like protein 1). It binds to a folded domain, amino acids 200–530.
L3MBTL1 is a Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a “reader” of a network of post-translational modifications.
Target Information
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain.
It is localized to condensed chromosomes in mitotic cells, and overexpression in glioma cell lines results in improper nuclear segregation and cytokinesis producing multinucleated cells.
L3MBTL1 represents a Polycomb group gene; the encoded protein regulates gene activity via chromatin modification.
Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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