Thermo Fisher Scientific SETD7 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-C220)
SETD7 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체. WB, ICC, Flow, ELISA 등 다양한 응용에 적합. HEK293 세포에서 발현된 비결합형 IgG 항체로, Protein A로 정제됨. SETD7의 H3K4 단메틸화 기능 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.01–0.1 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Flow Cytometry (Flow) | 1:100 | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| ChIP assay (ChIP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C220 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing SETD7 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074780 |
Product Specific Information
Specificity: This antibody recognizes SETD7 (Histone-lysine N-methyltransferase SETD7). It binds to a folded domain, amino acids 2–366.
SETD7 is a histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
It plays a central role in the transcriptional activation of genes such as collagenase or insulin.
Target Information
SETD7 is a histone methyltransferase that monomethylates Lys-4 of histone H3, serving as an epigenetic marker for transcriptional activation.
It plays a key role in activating genes like collagenase and insulin, and is recruited by IPF1/PDX-1 to the insulin promoter.
SETD7 also methylates non-histone proteins such as p53/TP53, TAF10, and possibly TAF7, enhancing their transcriptional activities.
Monomethylation of Lys-189 in TAF10 increases its affinity for RNA polymerase II, and Lys-372 methylation of p53 stabilizes and activates p53-mediated transcription.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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