Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
Rabbit polyclonal antibody targeting human alpha-synuclein for WB and IHC(F) applications. Recognizes residues 11–16 common to alpha-, beta-, and gamma-synuclein. Lyophilized, unconjugated form; reconstitute in sterile water. Ideal for neurodegenerativ...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues AKEGVVAAAEKTKQGV of a consensus part of human alpha-, beta-, and gamma-synuclein proteins (aa 11–16). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1077525 |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, store aliquots at -20 °C for higher stability, or at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Alpha-synuclein is a member of the synuclein family, which includes beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease pathogenesis. Alpha-synuclein peptides are major components of amyloid plaques found in Alzheimer’s disease brains. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA1-18253_alpha_Synuclein_P37840-1_Rabbit.svg, PA1-18253_alpha_Synuclein_P37840-1_Rabbit_PDP.jpeg)
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